To the best of our knowledge, studies on the relationship between OXPHOS metabolism and EMT in CSCs are limited, and only one published study showed that mitochondria OXPHOS metabolism reprogramming through FUNDC1, an effector mitophagy protein, enables cancer cells to adapt to microenvironment stress via heightened cell motility and metastatic propensity, leading to an escape from such an unfavourable environment [52]. This evidence concerns the gene FUNDC1 and cancer.