To understand the changes in non‐receptor‐mediated pathways during hypoxia‐induced oral cancer cell mitophagy, unlike BNIP3, the levels of PINK1, pPARKIN and PARKIN proteins were slightly increased in OECM‐1 CSCs after 6 and 16 h of hypoxia exposure compared to OECM‐1 cells. This evidence concerns the gene PINK1 and lip and oral cavity carcinoma.