CADINS appears with severe atopic disease (e.g., atopic dermatitis, rhinoconjunctivitis, food allergy, EoE, and/or asthma), respiratory tract infections and cutaneous viral infections, as well as immune dysregulation with Th-2 skewed immune response with increased IgE and eosinophilia, normal/low B-cell numbers, normal absolute T- and NK-cell numbers, impaired T-cell proliferation, and possible hypogammaglobulinemia with altered response of the specific antibody [36]. This evidence concerns the gene IGHE and eosinophilic esophagitis.