Signal transducer and activator of transcription (STAT) 3 (STAT3)-autosomal dominant (AD)-HIES (also known as Job Syndrome) is characterized by eczema, skin abscesses, chronic mucocutaneous candidiasis (CMC), recurrent pneumonia leading to pneumatoceles, and skeletal and connective tissue abnormalities (e.g., bone fragility, scoliosis, decidual teeth retention, vascular abnormalities). Here, STAT3 is linked to Alzheimer disease.