AR LOF mutations in capping protein regulator and myosin 1 linker 2 (CARMIL2) can cause CID associated with severe atopic dermatitis, elevated IgE, allergic asthma, food allergy, cold urticaria, recurrent bacterial and fungal infections – including invasive tuberculosis and mucocutaneous candidiasis – EBV lymphoproliferation and other malignancies [40]. Here, IGHE is linked to combined immunodeficiency.