LOF mutations in Dedicator of cytokinesis 8 (DOCK8) can cause a combined immunodeficiency that is noteworthy for severe viral skin infection [e.g., Human Papillomavirus (HPV), molluscum contagiosum, Herpes Simplex Virus (HSV) 1 and 2] – increasing risk for malignancies (e.g. HPV-associated squamous cell carcinomas, rapidly progressive T-cell lymphoma) – in addition to severe bacterial respiratory sinopulmonary infection. Here, DOCK8 is linked to Immunodeficiency.