The aim of this systematic literature review and meta‐analysis was to compare asparaginase (ASP)‐containing pediatric‐inspired regimens (PIRs) with hyper‐fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper‐CVAD) in adolescents and young adults (AYAs) with ALL/LBL. Here, ASPG is linked to acute lymphoblastic leukemia.