PTPRC and atherosclerosis: In accordance with our observations that autophagy is not equivalently induced in young and old macrophages upon pro-atherogenic lipid loading (Figure 2), immunofluorescence analyses of p-ATG16L1 in aortic root plaques revealed a greater autophagy induction during atherosclerosis regression in CD45+ leukocytes from the Y-BMT cohort (fold change, 2.04) as compared with the O-BMT cohort (fold change, 1.37; Figure 4A and 4B).