ACHE and Alzheimer disease: In particular, harmine and its derivatives have been reported as inhibitors of several biomolecular targets implicated in AD, such as Aβ aggregation, AChE, MAOs, 5-hydroxytryptamine (5-HT) and N-methyl-D-aspartate (NMDA) (Beato et al., 2021; Li et al., 2023).