Transcription factors such as Sterol Regulatory Element-Binding Protein-1 (SREBP-1) and Peroxisome Proliferator-Activated Receptors (PPARs) promote the expression of key genes like fatty acid synthase (FASN) and stearoyl-CoA desaturase 1 (SCD1), resulting in elevated lipid synthesis, enhanced cancer cell proliferation, and unfavorable prognosis in hepatocellular carcinoma(HCC) patients (17). The gene discussed is SREBF1; the disease is hepatocellular carcinoma.