Recent studies suggest that USP7 plays a role in lipid synthesis in cholangiocarcinoma(CCA) and head and neck squamous cell carcinoma(HNSC).USP7 has been shown to interact with and deubiquitinate ZNF638, and it can also promote the transcription of ZNF638 by stabilizing cAMP response element-binding protein (CREB). This evidence concerns the gene ZNF638 and head and neck squamous cell carcinoma.