APAF1 and hepatocellular carcinoma: The anti-cancer activity of UDCA on HCC xenografts in mice through increased expression of pro-apoptotic proteins including Bcl-2 associated X protein (Bax), apoptotic protease activating factor-1 (APAF1), cleaved-caspase-9 and cleaved-caspase-3 proteins have reported by Liu et al.