In contrast, genes that are involved in the IL-17 pathway (such as RPS6KA5, MAPK1, NFKB1, DUSP6) and MyD88-independent TLR4 cascade (i.e., CASP8, 1, DUSP6, UBE2D2, MAPKAPK2) were significantly upregulated in PB M-MDSCs consistent with increased cytokine signaling in M-MDSCs in the circulating M-MDSCs of DLBCL individuals. The gene discussed is CASP8; the disease is diffuse large B-cell lymphoma.