CERS5 and neoplasm: For instance, CerS1 produces ceramides(18:0), which inhibit tumor growth (Wang Z. et al.,2017), while CerS5 and CerS6 generate ceramides (16:0),which are associated with anti-apoptotic effects in headand neck squamous cell carcinoma (Moro et al., 2019).The CerS1-specific inhibitor P053 reduces ceramide (18:0)levels in HEK 293 cells (Turner et al., 2018).