MAPT and epilepsy: The hippocampus and amygdalae are of particular interest as these are early sites of accumulation of pathologic protein misfolding in neurodegenerative conditions.17,41 Aging-related pathologies such as phosphorylated tau and amyloid are pro-epileptogenic and could represent the aetiology of epilepsy in a subset of our cohort.19 To our knowledge, our study is the first to show lower amygdalae volumes in LOUE, suggesting that it might be one of the first neuroanatomical sites involved in this disease, although the magnitude of difference was small.