Beyond these examples, SIRT5 has also been found to inhibit gastric cancer invasion by catalyzing the desuccinylation of S100A10 protein (158), and it can desuccinylate the K280 site of serine hydroxymethyltransferase 2 (SHMT2) protein, thereby inhibiting osteosarcoma development (159). This evidence concerns the gene SHMT2 and osteosarcoma.