EBI3 and Alzheimer disease: In humans, gene microarray analysis of the choroid plexus from postmortem brain tissues of AD patients and normal controls also demonstrated increased expression of EBI3 in AD, a subunit of IL-35, and single-cell RNA-seq data from peripheral blood mononuclear cells further revealed increased variability in B cell expression in human AD as well as the expression of several subtypes of B regulatory cells (178).