MAP3K8 and neoplasm: During the examination of the transcriptional data from 155 ESCC samples, an assessment was conducted on the three genes (MAP3K8, SECTM1, IGLV7-43) within the prognostic model, it was found that MAP3K8 was significantly higher in adjacent normal tissues than in tumor tissues, while SECTM1 was significantly higher in tumor tissues than in adjacent normal tissues (Figure 5A).