As an exogenous ligand for the AhR, the Sulforaphane (SFN) can regulated the intestinal microflora of high-fat diet mice to prevent NAFLD by activating the AhR/SREBP-1C pathway, reduced the protein levels of indole-3-acetic acid (IAA), sterol regulatory element-binding protein-1c (SREBP-1C), acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FAS), And then regulates hepatic lipid metabolism, And to prevent NAFLD (Xu et al., 2021). The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.