In high sugar-induced insulin resistance and diabetes complications, AhR is crucial for maintaining ILC3, promoting the development and maturation of ILC3, and stimulating the secretion of IL-22 by ILC3 to inhibit inflammation levels, thereby preserving intestinal homeostasis (Artis and Spits, 2015; Kobayashi et al., 2014). The gene discussed is AHR; the disease is Insulin resistance.