AhR activation reduces IL-6 secretion by inhibiting the NF-κB pathway induced by LPS, IL-6 activates stat3 and inhibits the transcription and expression of zinc transporter SLC39A5, AhR enhances IL-10 levels by upregulating Src-STAT3 signaling triggered by LPS, alleviating lipid metabolism disorders. This evidence concerns the gene STAT3 and Disorder of lipid metabolism.