TP53 and neoplasm: As a tumor suppressor, wildtype p53 controls cell death in a highly redundant fashion, regulating five forms of cell death: 1) apoptosis, 2) ferroptosis, 3) necroptosis mediated by TNF, 4) necroptosis mediated by FAS ligand, and 5) senescence with an associated memory immune response (Levine, 2020b).