TP53 and neoplasm: There are several core metabolic elements in ferroptosis – including iron levels, ROS, GPX4/p21, FSP1, iNOS, GCH1, and iPLA2β, among others – that are tightly linked to tumor biology, and each has been demonstrated to be affected by p53 expression (Dixon and Stockwell, 2019; Liu and Gu, 2022a; Venkatesh et al., 2020; Soula et al., 2020; Kapralov et al., 2020; Malley et al., 2018).