For example, in a subtype of glioblastoma multiforme (GBM) known as primary GBM, 70% of glioma cells express wildtype p53 and these cells have been observed to have a selective impairment of the apoptotic functions of WT p53, while still being able to regulate p53 control over DNA repair and control of cell cycle (Shu et al., 1998). The gene discussed is TP53; the disease is central nervous system cancer.