Evodiamine inhibits the proliferation and induces apoptosis of cholangiocarcinoma cells, inhibits the migration and invasion of cholangiocarcinoma cells, suppresses IL-6/STAT3 signal transduction by upregulating the expression of SHP-2, and treats cholangiocarcinoma (Zhu et al., 2019). The gene discussed is PTPN11; the disease is cholangiocarcinoma.