VEGFR-1 is the exclusive receptor for other VEGF family members (Papetti and Herman, 2002; Ceci et al., 2020) and is essential for hematopoiesis, matrix metalloproteinase (MMP) activation, and the migration of monocytes and other immune cells into the tumor microenvironment (TME) (Ferrara et al., 2003). The gene discussed is VEGFA; the disease is neoplasm.