Since 2009, Scott et al. first confirmed that GOLPH3 is an oncogene in Nature magazine (Scott et al., 2009), it has been confirmed to be highly expressed in colorectal cancer, lung cancer, breast cancer, and advanced adenocarcinoma, correlating with the occurrence and development of tumors (Hua et al., 2012; Li et al., 2012; Zhou et al., 2012; Zeng et al., 2012). The gene discussed is GOLPH3; the disease is colorectal cancer.