We have found that activation of the NF-κB signaling pathway can inhibit apoptosis of glioma cells (Xu et al., 2020; Guo et al., 2019), and the activation of NF-κB in gliomas can inhibit the activation of JNK signaling, thereby suppressing the apoptosis of glioma cells (Gupta et al., 2013; Srivastava et al., 2011). The gene discussed is NFKB1; the disease is central nervous system cancer.