EA stimulation of Shangxing (GV23) and Fengfu (GV16) can improve cognitive impairment in rats by suppressing oxidative stress and neuroinflammation (35); Another study found that EA downregulated LC3 II/LC3 I and autophagosomes, and upregulated the expression of p62, mTOR and Beclin-1 in MCAO rats. This evidence concerns the gene BECN1 and Cognitive impairment.