The results showed that GBM patients who developed MGMT methylated patients exhibited significantly higher Ktrans values compared to MGMT unmethylated, a finding that not only revealed a strong association between DCE imaging parameters and MGMT methylation status but also by setting Ktrans >0.086 as the optimal cut-off value, with an AUC of just 0.756. This evidence concerns the gene MGMT and glioblastoma.