It represents a potential differential diagnosis with plasmablastic myeloma, plasma cell myeloma, and other B-cell lymphomas with plasmablastic differentiation such as anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma, human herpesvirus 8 (HHV-8)-associated large B-cell lymphoma, and primary effusion lymphoma [4]. This evidence concerns the gene ALK and B-cell non-Hodgkin lymphoma.