NPPB and heart failure: The outcomes measuring the effectiveness of the drug included cardiovascular mortality, hospital readmissions, and exercise capacity, in addition to changes in HR, LVEF, Minnesota Living with Heart Failure (MLWHF) questionnaire, N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), brain natriuretic peptide (BNP) levels, and left ventricular volume.