TNF and schizophrenia: At the same time, there are several investigations, in which interconnections have been established between the level of some markers of systemic inflammation and clinical characteristics of schizophrenia including the intensity of cognitive function impairment (TNF-α, IL-2, IL-6, IL-8, cortisol), neurocognitive defect (IL-1β, sIL-1RA, TNF-α), acute or chronic course of the disease (TNF-α, IL-2, IL-6, IL-8, cortisol) [22, 23].