We identified 10 genes—CDH3, COL3A1, CP, CRLF1, CTHRC1, POSTN, POU2AF1, SAMD11, SLC44A4, and THY1—from a total of 67 DEGs through LASSO regression, which were found to be the best predictors of IPF. This evidence concerns the gene COL3A1 and idiopathic pulmonary fibrosis.