For instance, Hedyotis diffusa injection (HDI) has been found to induce ferroptosis in lung adenocarcinoma cells by increasing ROS release through the Bax/Bcl2/VDAC2/3 axis, independently of GPX4 and the PUFA-PLS pathway (Huang et al., 2022). Here, GPX4 is linked to lung adenocarcinoma.