Liu Shuang and colleagues investigated lncRNA-microRNA interactions, chromatin modifiers, and ferroptosis in lung cancer, as well as the oncogenic role of GINS4, the tumor-suppressive function of GPR162 in radiotherapy, the impact of AhR on NSCLC, and the targeting of USP8 in HCC treatment. Here, USP8 is linked to non-small cell lung carcinoma.