LIAS and cancer: Cuproptosis, a copper-dependent form of cell death, has been implicated in cancer progression, with pan-cancer analyses revealing that mutations in cuproptosis-associated genes (e.g., ATP7A, ATP7B, LIAS) correlate with survival outcomes and immune microenvironment modulation in multiple cancer types, including kidney and uterine cancers (Liu and Tang, 2022a; Liu and Tang, 2022b; Liu, 2023).