The fC1INH ELISA and fC1INH chromogenic assays were tested in a subset of samples (29 samples from patients [11 male and 18 female patients] with previously diagnosed recurrent angioedema due to C1INH deficiency [28 patients with HAE-C1INH and 1 patient with acquired angioedema due to C1INH deficiency] and 50 samples from healthy subjects [20 male and 30 female subjects]; Table I). This evidence concerns the gene SERPING1 and angioedema.