eGFR - estimated glomerular infiltration rate; iMCD - idiopathic multicentric Castleman disease; JAK - Janus kinase; TAFRO - the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype; TNF-α - tumor necrosis factor-alpha. This evidence concerns the gene TNF and idiopathic multicentric Castleman disease.