BSCL2 and autosomal recessive disease: Congenital generalized lipodystrophy syndromes are autosomal recessive diseases, mainly due to null variants in AGPAT2, involved in the glycerophospholipid/triacylglycerol biosynthesis pathway (134), or in BSCL2 which encodes a 398-amino acid integral endoplasmic reticulum membrane protein called seipin that take part in lipid droplet formation and adipocyte differentiation (135).