Congenital generalized lipodystrophy type 3 and congenital generalized lipodystrophy type 4 are due to genetic mutations in caveolin-1 and cavin-1, respectively, both of which are crucial for the formation of caveolae, specialized microdomains of the cell plasma membrane that activate various signaling pathways. Here, CAVIN1 is linked to congenital generalized lipodystrophy type 4.