Only one biomarker was selected from each functional group, and the combination of ALX3, NPTX2 and TRIM58 achieved the highest average prediction accuracy of 93.3% for the five initially selected cancers (brain, esophageal, liver, lung, and pancreatic cancers) and the additionally selected five common cancers (breast, colorectal, prostate, bladder, and stomach cancers). The gene discussed is NPTX2; the disease is gastric cancer.