ALX3 and cancer: Only one biomarker was selected from each functional group, and the combination of ALX3, NPTX2 and TRIM58 achieved the highest average prediction accuracy of 93.3% for the five initially selected cancers (brain, esophageal, liver, lung, and pancreatic cancers) and the additionally selected five common cancers (breast, colorectal, prostate, bladder, and stomach cancers).