FOXM1 and cancer: Research by L Gai et al. found that the protein expression of FOXM1 is significantly upregulated in esophageal squamous cell carcinoma, knockdown the FOXM1 can inhibit the migration and invasion ability of cancer cells, and is significantly positively correlated with lymph node metastasis, clinical stage, and tumor infiltration depth (Gai et al., 2016).