CDK1 and esophageal adenocarcinoma: In addition, as early as 2005, Donna E Hansel et al. compared the gene expression profiles of normal esophageal epithelial cell lines and esophageal adenocarcinoma cell lines and found that CDK1 was significantly upregulated in esophageal adenocarcinoma and was a marker of dysplasia and a drug potential targets (Hansel et al., 2005).