PIK3CA and esophageal squamous cell carcinoma: Previous studies have shown that AURKA can cooperate with TPX2 to regulate the progression of esophageal squamous cell carcinoma through EGFR/PI3K/Akt pathways (Du et al., 2023; Du et al., 2020), it can also regulate the expression and phosphorylation level of JAK2 to promote the activity of STAT3, this mechanism plays an important role in gastric cancer and esophageal cancer (Katsha et al., 2014).