Wang et al. constructed a comprehensive genome map of PESC for the first time (Wang et al., 2018), They conducted whole-exome, SNP chip detection and high-depth targeted sequencing analysis on 55 patients, and found three significant but not yet reported and mutated genes PDE3A, PTPRM, CBLN2. Li et al. conducted genome and transcriptome analysis on 65 SCCE patient tissues and found that SCCE has RB1 destruction mediated by multiple mechanisms (Li et al., 2021a). The gene discussed is PDE3A; the disease is cervical small cell carcinoma.