A potential explanation for this finding is the fact that defective laminin-332 signaling in the skin of patients with JEB is known to deplete EpiSCs owing to phosphorylation and sequestration of the key stem cell marker YAP1, precluding its import into the nucleus (De Rosa et al, 2019) (Supplementary Figure S9). The gene discussed is YAP1; the disease is junctional epidermolysis bullosa.