TIMP1 regulates the remodelling of the extracellular matrix by inhibiting metalloproteinase activity, which helps tumour cells adapt to changes in the matrix, thereby enhancing cell survival by inhibiting apoptosis (Guccini et al., 2021; Justo and Jasiulionis, 2021), potentially affecting blood vessel formation during MVI. Here, TIMP1 is linked to neoplasm.