PPP2R2A, which is also increased in T cells from patients with SLE, enhances TH1 and TH17 cell differentiation through activation of the guanine nucleotide exchange factor H1/Ras homolog family member A/ROCK (GEF-H1/RhoA/ROCK) signaling pathway [74]. The gene discussed is RHOA; the disease is systemic lupus erythematosus.