PTPN6 and Autoimmunity: Although neutrophil-specific depletion of SHP1 does not lead to autoimmunity, the mice manifest a spontaneous cutaneous inflammatory disease by enhanced neutrophil integrin signaling through Src-family and Syk kinases [104], or by promoting the secretion of TNF and IL-1α/β from neutrophils through caspase-8- and Ripk3/Mlkl-dependent pathways [105].