Oral administration of spermidine (0.1 M solution) reduces weight loss, colonic inflammation, and damage in an experimental colitis mouse model, probably due to the enhanced TC-PTP-dependent IFN-γ-induced phosphorylation of STAT1/3 and p38 MAPK and expression levels of ICAM-1, MCP-1, and IL-6 in monocytes [149]. This evidence concerns the gene IL6 and colitis.