PTPN6 and autoimmune disease: In addition, mice with a hypomorphic allele of PTPN6 (m1Btlr, designated spin), which causes a homozygous Tyr208Asn amino acid mutation in SHP1, develop neutrophilic dermatosis-like chronic inflammatory and autoimmune disease, which depends on IL-1/MyD88 [97], and ASK1/2 signaling [98].