The pathological morphology of ground-glass pulmonary nodules often undergoes atypical adenomatous hyperplasia (AAH) → adenocarcinoma in situ (AIS) → minimally invasive adenocarcinoma (MIA) → invasive adenocarcinoma (IAC) (51), even in patients with EGFR mutations (52). This evidence concerns the gene EGFR and adenocarcinoma in situ.