The 48,440 people did not have blood test data for cedar pollen IgE antibody titre and also excluded from this study were higher percentages of age≥ 65 years (47.4%), and male (38.7%), and lower percentage of BMI ≥ 25 kg/m2 (29.9%), daily alcohol intake (17%), current smoke (34.9%), physical activity of walking ≥1 time/week (22.2%), sleep duration of 6–7 hours/day (36.4%), medication use for hypertension (25.4%), diabetes mellitus (6.3%), and dyslipidemia (11.4%)., The results of logistic regression analysis are shown in Table 2. The gene discussed is IGHE; the disease is metabolic syndrome.