The most common AEs of any grade linked to TDM‐1 included thrombocytopenia (RR 7.14, 95% CI 4.13–12.36) and increased ALT (RR 2.04, 95% CI 1.43–2.91), with also a trend for a higher risk of ≥G3 AEs (RR 5.58,95% CI .77–40.26) and RR 1.59, 95% CI .50–5.11, respectively). This evidence concerns the gene GPT and Thrombocytopenia.