Moreover, advanced chemoattraction and migration of monocytes, their subsequent polarization into inflammatory macrophage phenotypes, and secretion of IL‐1ꞵ, IL‐6, and TNF‐α are also extensively observed to occur via LTB4 in obesity and from adipose tissue (Spite et al. 2011; Ying et al. 2017). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.