It has been widely suggested in preclinical obesity models that the 5‐LO/LTB4/BLT1 pathway positively influences the secretion of IL‐6, TNF‐α, and IL‐1β (Bonyek‐Silva et al. 2020; Horrillo et al. 2010; P. Li et al. 2015; Mothe‐Satney et al. 2012; Spite et al. 2011; Ying et al. 2017). The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.