This intricate relationship among LTB4, BLT1, and MCP‐1 could be an intriguing therapeutic target for cardiometabolic‐associated arrhythmia given the heightened levels of MCP‐1 protein in the atria of T2DM mice, as well as their attribution to ryanodine receptor 2 (RyR2)—a Ca‐handling protein—activation and AF susceptibility (Ren et al. 2024; Zhou et al. 2024). Here, RYR2 is linked to atrial fibrillation.