SGLT2-Is have pleiotropic effects, including the improvement of glycemic control by blocking glucose reabsorption in the proximal convoluted tubule of the kidney and thereby reducing oxidative stress in the kidneys [2], and they were shown to reduce HF patient hospitalizations and mortality [3,4] and to increase exercise capacity and quality of life [5,6]. Here, SLC5A2 is linked to hydrops fetalis.