The 11 pathways could be divided into four categories: environmental information processing (e.g., Viral protein interaction with cytokine and cytokine receptor), metabolism (e.g., Caffeine metabolism), organismal systems (e.g., complement and coagulation cascades, platelet activation, PPAR signaling pathway, neutrophil extracellular trap formation, and cholesterol metabolism), and human diseases (e.g., coronavirus disease-COVID-19 elt, (Figure 4A). The gene discussed is PPARA; the disease is COVID-19.