Our research plan relies first on searching the COSMIC (Catalogue of Somatic Mutations in Cancer) [27] database for cancer-related SASH1 variants carrying missense mutations in the Sam1 domain and then, through several bioinformatic tools and molecular dynamic simulations, studying how these mutations could affect the stability of SASH1-Sam1 alone, leading eventually to a defective fold. The gene discussed is SASH1; the disease is cancer.