EPHA2 and cancer: Other SASH1-Sam1 variants, like the E670D and the D674N, are predicted to have a marginal effect on the stability of SASH1-Sam1 alone and on its interaction with EphA2-Sam, thus letting us speculate that their correlation to cancer could be associated with inhibition of SASH1-Sam1-mediated interactions with partners different from EphA2-Sam.