PD presents neuroinflammatory aspects, such as increased innate immune responses, with the elevated expression of TLR2, TLR5, TLR4, and CD14; activation of natural killer cells; and increased levels of IL-1β, IL-6, TNF-α, IL-2, IL-4, interferon-λ, and complement factors C3 and C9 [66,67]. This evidence concerns the gene TLR4 and Parkinson disease.