The administration of LPS via intranigral injection results in a reduction in the time spent in the open arm in the elevated plus-maze test, indicating depressive and anxious-like behavior (symptoms that precede PD), likely caused by the reduction in dopaminergic and noradrenergic neurons and brain-derived neurotrophic factor (BDNF), which is important for synaptic plasticity and memory processes [230]. The gene discussed is BDNF; the disease is Parkinson disease.