Vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) belong to the family of tyrosine kinase receptors (RTKs), which are frequently mutated and/or overexpressed in different kinds of human cancers, namely lung, breast, and colorectal carcinoma. The gene discussed is EGFR; the disease is colorectal carcinoma.