Ye and coworkers designed and synthetized the series of 5,7-dimethyl-oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives, which were evaluated for their FGFR1-inhibition ability as well as cytotoxicity against three cancer cell lines (mouse melanoma B16F10 and human lung cancer H460 and A549) in vitro [33]. Here, FGFR1 is linked to cancer.