GCLM and breast cancer: Furthermore, γ-tocopherol significantly increases the proteins levels of NQO1 (NAD(P)H quinone dehydrogenase 1), GCLM (glutamate-cysteine ligase modifier subunit), and HO-1 in mammary tumors in mice subjected to E2-induced alterations, thereby mitigating oxidative stress, which helps to prevents cellular homeostasis [35] (Figure 2).