We identified a plethora of TFs associated with hypoxic conditions in BC, including p53, GATA3, CTNNB1, SNAIL, SLUG, STATs, SMAD, ZMYND8, TWIST1, NF-Kb, c-Myc, several FOX family members, ESR1, PRG, and YAP1. The gene discussed is ESR1; the disease is breast cancer.