WWTR1 and breast cancer: Hypoxia in BC can affect the expression, subcellular localization, or activity of Yes-associated protein 1 (YAP) and WW-domain-containing transcription regulator 1 (WWTR1, known as TAZ), YAP/TAZ being transcriptional coactivators that regulate gene transcription in complex with members of the transcriptional enhanced associate domain (TEAD) family [228].