TF and breast cancer: We identified a cluster of HIF-related TFs that orchestrate the transcription of target genes involved in hypoxia, due to their post-translational modifications (PTMs), which drive TFs’ stability and activity, degradation and turnover (TF’s degradation and turnover), and bidirectional translocation between the cytoplasm or plasma membrane and nucleus of BC cells, as well as transcription/activation of proteins encoded by oncogenes or inactivation of tumor suppressor target genes.