Casillas et al. (2021) showed that HIF1 phosphorylation by serine/threonine–protein kinase PIM1, an oncogene found to be overexpressed in BC, especially in TNBC [120], at the Thr455 residue disrupts HIF1α hydroxylation, stopping its degradation pathway and promoting the transcription of target genes [121]. Here, HIF1A is linked to breast cancer.