In this review, we identified the most important PTMs of HIF1α involved in BC tumorigenesis and progression, as well as a cluster of TFs, that belong to the HIF1α interactome, which orchestrates the transcription of target genes involved in hypoxia due to their post-translational modifications (PTMs), including phosphorylation/dephosphorylation, ubiquitination/deubiquitination, SUMOylation, hydroxylation, acetylation, S-nitrosylation, and palmitoylation. Here, HIF1A is linked to breast cancer.