TF and breast cancer: The cellular response to oxygen deprivation is orchestrated by the hypoxia signaling pathway, governed by hypoxia-inducible factors (HIFs), belonging to transcription factor (TF) proteins, which induce and regulate the expression of hundreds of genes involved in BC cell survival and proliferation, glycolysis and other metabolic pathway rewiring, resisting programmed cell death, angiogenesis, invasion, and metastasis.