G6PC1 and type 2 diabetes mellitus: Liao et al. [60] studied the establishment of a mouse model of T2DM by injection of streptozotocin (STZ), and the results showed that oral administration of pea peptides (1000 mg/kg BW) reduced blood glucose from 19.92 mmol/L to 14.3 mmol/L and significantly inhibited the phosphorylation expression of cAMP response element-binding protein(CREB) and glucose-6-phosphatase catalytic subunit (G6PC) in the hepatic gluconeogenesis signaling pathway.