Specifically, we focused on the role of key lncRNAs, miRNAs, and mRNAs in LUADBM progression, with a particular emphasis on the XLOC_006941/hsa-miR-543/NPRL3 axis, and the involvement of GATA3 and Th2 cells in shaping the tumor microenvironment. The gene discussed is NPRL3; the disease is neoplasm.