POSTN and metastatic malignant neoplasm in the lymph nodes: Among these clinicopathologic factors, the multivariate analysis revealed that periostin in CAFs-positive expression (p < 0.001), age ≥ 65 years (p = 0.006), poorer differentiation (p = 0.001), and lymph node metastasis (p = 0.019) were significantly correlated with poor survival.