Given the dominant effect of histologic grade on survival in AC, along with the potentially confounding effects of patient age, tumor volume (PCI) and tumor grade, multivariable analysis was performed, confirming that the prognostic significance of the CD8+:CD3+ cell density ratio was independent of age, grade and site of tissue biopsy (HR 0.39, 95%CI [0.20, 0.73], p = 0.004; Table 5/Figure 5). Here, CD8A is linked to neoplasm.