Notably, recurrent mutations in SETD2 (e.g., T2338Hfs31 in exon regions, n = 2) and PBRM1 (e.g., D1055Y, n = 2; W1417, n = 2) were absent from the COSMIC database’s chordoma entries, indicating potential novel hotspots. This evidence concerns the gene SETD2 and chordoma.