MTAP and non-small cell lung carcinoma: Interestingly, inhibition of MTAP enzymatic activity in immunodeficient mice produces a systemic increase of the MTA concentration, which abrogates A549 and H358 xenograft tumor growth, cell lines derived from human non-small cell lung carcinoma and human bronchioalveolar non-small cell lung carcinoma cells lines, respectively [13,182].