APEX1 and hepatocellular carcinoma: This kind of alteration has been linked to numerous human HCCs during their development and, moreover, the apurinic/apyrimidinic endonuclease 1 (APEX1) that should protect cells against genomic instability, was found to be downregulated in Mat1a KO mice in a SAMe-dependent manner suggesting an important role of DNA hypomethylation in the development of HCC [100,102].