In addition, both MAT2B splicing variants are able to interact with G Protein Coupled Receptor Kinase Interacting ArfGAP 1 (GIT1) recruiting and activating mitogen-activated protein kinase kinase (MEK) and ERK promoting growth and tumor formation [128], and also activating Ras/Raf [129]. The gene discussed is GIT1; the disease is neoplasm.