In the case of drug-induced liver injury (DILI), the levels of the liver damage markers alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH) were reduced after SAMe supplementation in patients under chemotherapy treatment [264], and in resected CRC patients treated with adjuvant FOLFOX regimen, in which also reduced cancer-related fatigue [265,266]. This evidence concerns the gene GPT and colorectal carcinoma.