In addition, the study of a Mat1a KO-derived HCC cell line (SAMe-D) demonstrated that LKB1 regulates Akt (protein kinase B)-mediated survival through its hyperphosphorylation and also blocks the apoptotic response through phosphorylation and retention of p53 in the cytoplasm [112]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.